Dr Marzo is an Associate Professor of Cardiovascular Biomechanics at the University of Sheffield, UK. 
His research expertise is firmly rooted in Engineering and Mathematics in the context of 
computational biomechanics, with a PhD on the mechanics of flow through elastic vessels from the 
University of Sheffield, a David Crighton Research Fellowship at the University of Cambridge, and 
participation in several EU/UK projects, focusing on cardiovascular flow characterisation and 
development of computational frameworks. His expertise has a strong emphasis on clinical 
interpretation and translation, with his time spent as Clinical Scientist for the UK National Health 
Service. This experience gave AM exposure to the UK healthcare system, where he has witnessed the 
often-difficult clinical perception of innovation, and the resulting challenges relating to technology 
adoption.

The role of collaterals in treatment of intracranial aneurysms
Intracranial aneurysms are balloon-like focal deformations of a blood vessel in the brain, carrying an inherent risk of rupture and bleeding with severe consequences for the patient. A minimally invasive treatment option consists of deploying a medical device (Flow Diverting Stent or FDS) to trigger blood coagulation inside the aneurysmal sac to stop or prevent any existing or potential bleeding. In certain circumstances this treatment causes the occlusion of the arteries surrounding the aneurysm, leading to permanent and often irreversible damage (stroke). There is a strong consensus in the literature that the underlying causes might be associated with stent-induced adverse alterations to blood flow in the vascular network surrounding the aneurysm. Using a 3D-0D multidimensional patient-specific models of blood flow through an extended portion of the Circle of Willis, this study explores the possible role of collateral networks that are often associated with FDS-induced post-treatment complications. The long-term aim is that of providing guidance to clinicians towards a safer and more effective treatment of this condition.