Location

Château Belmont :
57, Rue Groison - 37100 TOURS - FR

Château Belmont, an establishment steeped in history, welcomes you to a 17th-century building surrounded by 2.5 hectares of parkland. Once planted with vines renowned for their south-facing aspect, the château became a hospital during the 1870 war.
After the war, Baroness Tellier de Blanrier acquired the property in 1880 and had the ceiling of the living room painted. In 1885, the vines were replaced by apple trees, which produced cider for over sixty years.
Passionate about flowers, the next owners decided to turn the estate into a tulip research centre.
In 1987, Jean and Sophie Bardet opened a restaurant. Jean Bardet, a renowned chef, offered creative, gourmet and refined cuisine.
The AEGIDE-Domitys group opened its first hotel in 2008, bringing Château Belmont to life.
Discover this place steeped in history, where the elegance of the past blends harmoniously with modern comforts. Treat yourself to an unforgettable stay in an enchanting setting, steeped in the richness and charm of its prestigious past.

How to get there ?

By train:

* Tours centre station
 1.5 hour trip from Paris (Montparnasse)

 * Saint Pierre des Corps (4km from Tours town centre)

Bus 5, 20 minutes trip to Tours centre station

> Plan your trip by train: https://www.sncf-connect.com/en-en/

By tramway:

20 minutes trip from Tours centre station

> Take Tramway A in direction to Vaucanson, step out at Tranchée stop

Château Belmont is an 8-minute walk from the stop.

By bus:

25 minutes trip from Tours centre station

> Take Bus 10 in direction to Beffroi, step out at Charles Barrier stop

Château Belmont is an 9-minute walk from the stop.

By car:

GPS: 47.4079083,0.6871076
Please note that you can't park in the courtyard in front of the Château Belmont.
Paid car park nearby : 
Parking Relais: Tranchée - Fil Bleu, 16 Rue des Bordiers, 37100 Tours
 

By plane:

*Arrival at Roissy Charles De Gaulle (CDG) airport: 
Take RER B in direction to Saint Rémy Les Chevreuse, step out at Denfert Rochereau Stop
Metro 6 in direction to Charles de Gaulle Etoile, step out at Montparnasse Bienvenue Stop 

> Then take a train to Tours (see "by train" section above)

*Arrival at Paris-Orly (ORY) airport: 

Take Orlyval Shuttle from Aéroport d’Orly in direction Antony, step out at Antony Stop

Take RER B in direction to Mitry Clave, step out at Denfert Rochereau Stop

Take Metro 6 in direction to Charles de Gaulle Etoile, step out at Montparnasse Bienvenue Stop

> Then take a train to Tours (see "by train" section above)

 General Information

Château Belmont
57 rue Groison  - 37100 Tours, France

Monday, 23 June to Thursday 26 June 2025

The official language of the Congress is English

 Upon arrival you will receive a welcome pack that includes the printed material of the Conference and your name badge will be given to you at the reception . Please wear your name badge at all times during the Conference and to all official Conference events.

 An official letter of invitation facilitating the obtention of an entry visa can be sent upon request . In order to receive an invitation letter for visa purposes, send an email to maurine.villiers@lestudium-ias.fr. Please note that : 
- we only issue an official letter once the payment of the registration fee has been validated.
- such letters do not represent a commitment on the part of the Organisers to provide any financial assistance.

 After the conference, in order to receive a certficate of participation, send an email to maurine.villiers@lestudium-ias.fr

Short talks & posters

Abstracts for short talk and poster should be submitted before Monday 28th April 2025.

Please upload your abstract during the registration or send it before the deadline to maurine.villiers@lestudium-ias.fr.

The number of oral presentations is limited, convenors will process a selection and confirm your presentation few days later.

Please note that we do not print the posters, but racks & pins will be provided for up to A0 sizes, portrait format.

• Please download the template for oral presentation.
• Please download the template for poster presentation.

Pricing

Registration will open shortly

(Including three lunches, a wine & cheese cocktail and wine cellar visit and the coffee breaks)

Cancellation Policy
All cancellations must be made in writing and sent by email to the Registration Department
Up to 30 days prior to conference start – Full refund less €50 handling fee
Less than 30 days prior to conference start – No refund

Confirmed speakers

• David Julius, University of California-San Francisco, CA - USA
• Bruce Bean, Harvard University, MA - USA
• Holly Ingraham, University of California-San Francisco, CA - USA
• Mark T. Nelson, University of Vermont, VT - USA
• Richard S. Lewis, Stanford University, CA - USA
• Murali Prakriya, Northwestern University, IL - USA
• Patrick G. Hogan, La Jolla Institute, CA - USA
• Anjana Rao, La Jolla Institute, CA - USA
• L. Fernando Santana, University of California Davis, CA - USA
• Mohamed Trebak, University of Pittsburgh, PA - USA
• Marie Potier-Cartereau, University of Tours, FR
• David I. Yule, University of Rochester, NY - USA
• Scott Earley, University of Rochester, NY - USA
• Jonathan H. Jaggar, University of Tennessee, TN - USA
• Madeline Nieves-Cintron, University California-Davis, CA - USA
• Martha Cyert, Stanford University, CA - USA
• Rose Dixon, University of California-Davis, CA - USA
• Jeffrey Holt, Harvard University, MA - USA
• Alexander Sobolevsky, Columbia University, NY - USA
• Medha Pathak, University of California-Irvine, CA - USA
• Diana Bautista, University of California-Berkley, CA - USA
• Eduardo Perozo, University of Chicago, IL - USA
• Stefan Feske, New York University, NY - USA
• Dejian Ren, University of Pennsylvania, PA - USA
• Kenton Swartz, National Institutes of Health, MD - USA
• Grace E. (Beth) Stutzmann, Chicago Medical School, IL - USA
• Steven Marx, Columbia University, NY - USA
• Nicolas Demaurex, University of Geneva - CH
• Khaled Machaca, Cornell University-Qatar - QA
• Geert Bultynck, KU Leuven - BE
• Michel De Waard, University of Nantes - FR
• Olivier Soriani, University Cote D’azur, Nice - FR
• Anna Gomez, INSERM, Châtenay-Malabry, FR
• David E. Clapham, HHMI; Janelia Farms, VA - USA
• Liang Feng, Stanford University, CA - USA
• Seok-Yong Lee, Duke University, NC - USA
• Mike Salter, University of Toronto, ON - CA
• Zhaozhu Qiu, Johns Hopkins University, MD - USA
• Jeanne Nerbonne, Washington University at St Louis, MO - USA

Tourist visits in Touraine :

	Cathédrale Saint Gatien: This impressive cathedral boasts a facade adorned with detailed carvings and remarkable stained glass windows, a testament to flamboyant Gothic architecture. St-Gatien's Cathedral is open from 8.30am to 8pm every day of the week. It is located Place de la Cathédrale, 37000 Tours. You can reach them on 02 47 70 21 00.
	Place Plumereau: Situated in the heart of Vieux Tours, this lively square is surrounded by half-timbered houses and numerous cafés and restaurants, providing a friendly atmosphere in which to relax and observe local life.
	Basilique Saint Martin: An important place of pilgrimage, with its impressive architecture and crypt housing the saint's tomb. Saint Martin church is open from 7.15am to 7pm from Tuesday to Saturday. It is located 7 Baleschoux Street, 37000 Tours. You can reach them on 02 47 05 63 87.
	Charlemagne Tower : A real landmark in the town, the Charlemagne tower (and its neighbour, the Horloge tower) are the last remains of the medieval collegiate church of Saint-Martin, destroyed between 1798 and 1802. The Tour de l'Horloge (50m) was part of the main façade, while the Tour Charlemagne (56m) was the bell tower on the north arm of the transept. The Charlemagne Tower is open from Monday to Thursday (8.30am to 5pm) and Friday from 8.30am to 4.30pm. It is located 83 Halles Street, 37000 Tours. You can reach them on 02 47 21 61 88.
	Museum of Natural History of Tours : Located in the old town of Tours, just a stone's throw from Place Plumereau, the Natural History Museum offers permanent and temporary scientific exhibitions, as well as a vast vivarium area and a rich natural science documentation centre. The museum is open every day of the week from 9.30am to 12.30pm / 2pm to 6pm. It is located 3 President Merville Street, 37000 Tours. The museum is a 15-minutes walk from Tours station. You can reach them on 02 47 21 68 08. Full price €5 / Low price €2.50.
	Le Centre de Création contemporaine Olivier Debré : Right in the heart of the Loire châteaux region, the CCC OD provides the city of Tours with a prestigious creative venue of international renown. It is open from Wednesday to Sunday, 11am to 6pm and Saturday until 7pm. You can contact them : 02 47 66 50 00 / contact@cccod.fr . Prices from €5.50 to €8.50.

Castles :

	Château de Chenonceau: Nicknamed the ‘Château des Dames’, it is famous for its elegant architecture spanning the Cher and its refined gardens. The Château de Chenonceau can be reached by train in 30 minutes from Tours station. The château is a 2-minute walk from Chenonceau station. It is possible to book tickets to visit on the website : https://www.chenonceau.com/ . The full adult fare is €18, €16 for students, €15 for children from 7 to 18 years old.
	Château de Villandry: Known for its formal gardens, it offers an exceptional visual experience with its flower and vegetable beds. The castle is located 3 Main Street, 37510 Villandry. The castle is open from 9am to 6pm and gardens between 9am to 7pm. You can come by public transport from Tours with the bus for 1 hour. Information from the service provider: 02 47 66 70 70.
	Forteresse Royale de Chinon: This medieval castle offers a glimpse into French history and a breathtaking view of the River Vienne. It is located 2 Castle Street, 37500 Chinon. The forteresse is 40 minutes from Tours by car and 20 minute walk from Chinon station. It is open every day from 9.30am to 6pm. Prices range for €8.50 to €10.50.
	Château du Clos Lucé: The last home of Leonardo da Vinci, it features models of his inventions and a park dedicated to his works. It is located 2 Clos Lucé Street, 37400 Amboise. It is open every day from 10am to 64pm. The castle is accessible by train from Tours Station to Amboise and you have to walk 25 minutes to reach the castle. A bus service runs between the station and Amboise town centre all year round. You can contact them at 02 47 57 00 73.

Programme

Monday 23rd June 2025 – Paris Time (GMT +1)

• 08:00 Welcome coffee & registration
• 08:30 Official Opening – Phillipe Roingeard, Alain Eychene & Anne Besnier – Sophie Gabillet (General Secretary of LE STUDIUM)

SESSION 1 - Ca2+ signal transduction in health and disease

• 09:00 Martha Cyert - Mapping new signaling pathways for calcineurin
• 09:25 Patrick Hogan – Calcium, NFAT, and gene expression in 'exhausted' CD8 T cells
• 09:50 Anjana Rao – The TET-DNMT-ASXL-OGT axis: implications for clonal haematopoiesis, cancer, aging and autoimmune disease
• 10:15 Coffee break
• 10:45 Nicolas Demaurex – Role of store-operated and mechanosensitive channels in innate immune cells
• 11:10 Murali Prakriya – Regulation of microglial reactivity and neuroinflammation by Orai1 channels.
• 11:35 Mohamed Trebak – CRAC channels in smooth muscle (patho)physiology
• 12:00 Short Talk 1
• 12:15 Lunch break

SESSION 2 - Generation and shaping of Ca2+ signals

• 13:45 David Yule  – Intracellular Ca2+ release channels: shaping Ca2+ signals in time and space
• 14:10 Geert Bultynck – Ca2+ signaling at membrane contact sites: a focus on ryanodine receptors and Wolfram-syndrome-linked CISD2
• 14:35 Liang Feng – Molecular mechanisms of mitochondrial calcium uniporter
• 15:00 Khaled Machaca – Calcium tunneling. Calcium what?
• 15:25 Richard Lewis – Regulation of STIM and Orai at the single-molecule level
• 15:50 Coffee break

SESSION 3 - “New” ion channels

• 16:20 David Clapham – New organellar ion channels
• 16:45 Stefan Feske - Novel ion channels in immune cell function
• 17:10 Zhaozhu Qiu - From SWELL to PAC: discovery of novel chloride channels
• 17:35 Short Talk 2
• 17:50 Free evening

Tuesday 24th June 2025 – Paris Time (GMT +1)

SESSION 4 - Ion channel structure and function

• 08:30 Seok-Yong Lee – Molecular mechanism of a TRP channel gating
• 08:55 Kenton Swartz - Inactivation mechanisms in voltage-activated cation channels
• 09:20 Alexander Sobolevsky – Regulation and gating of ionotropic glutamate receptors
• 09:45 David Julius – Studying ion channel structures in more native membrane environments
• 10:10 Coffee break

SESSION 5 - Ion channels and mechanosensitivity

• 10:40 Jeffrey Holt - Mechanotransduction in auditory hair cells: A tale of two channels 
• 11:05 Eduardo Perozo - Evolutionary approaches to cellular and molecular mechanotransduction 
• 11:30 Medha Pathak - Molecular choreography of Piezo1 during development and repair
• 11:55 Short Talk 3
• 12:10 Short Talk 4
• 12:25 Lunch break

SESSION 6 - Ion channels in nerve and muscle

• 13:50 Jeanne Nerbonne - Intracellular fibroblast growth factors in the regulation/dysregulation of neuronal excitability 
• 14:15 Bruce Bean - Mechanisms of pacemaking in central neurons 
• 14:40 Steven Marx - Unravelling the mechanisms of fight or flight: how the heart responds to adrenergic signals 
• 15:05 Rose Dixon - Rad functions as a PKA-regulated endosomal retention factor for CaV1.2 channel trafficking in cardiomyocytes 
• 15:30 Short Talk 5
• 15:45 Short Talk 6
• 16:00 Poster session 1 
• 18:00 Gala Dinner - Château d’Amboise. Departure from Chateau Belmont

Wednesday 25th June 2025 – Paris Time (GMT +1)

• 08:00 Welcome coffee

SESSION 7 - Ion channel pharmacology and modulation

• 08:30 Mike Salter – Alternative splicing of NMDAR subunit GluN1 controls actions of ketamine
• 08:55 Michel De Waard – The emergence of natural peptides into the world of photopharmacology
• 09:20 Anna Gomez - Modulation of calcium release channels: Implications for cardiac rhythm and arrhythmias 
• 09:45 Marie Potier-Cartereau - Lipid regulation of SK channels 
• 10:10 Coffee break 

SESSION 8 - Ion channels and disease

• 10:30 Holly Ingraham - How estrogen leads to hypersensitivity in the gut in females
• 10:55 Olivier Soriani - Ion channels drive intercellular communication in pancreatic ductal adenocarcinoma”
• 11:20 Beth Stutzmann - Shared calcium channelopathies across neurological disorders
• 11:45 Dejian Ren - Lysosomal ion channels in neurodegenerative diseases
• 12:10 Diana Bautista - TRPA1 plays a key role in SARS-CoV-2 pain and airway inflammation
• 12:35 Lunch break
• 14:00 Poster session 2 & free afternoon
• 17:00 Reception evening at Chinon : Departure for Chinon 5pm. Wine tasting at Château de la Grille and Cocktail / surprise event

Thursday 26th June 2025 – Paris Time (GMT +1)

• 09:00 Welcome coffee

SESSION 8 - Ion channels and calcium in vascular regulation

• 09:30 Mark Nelson - .  Capillaries as multi-modal sensors of brain activity
• 09:55 L. Fernando Santana - Random yet rhythmic: How microvascular networks shape ATP dynamics and cardiac excitability
• 10:20 Coffee break
• 10:50 Jonathan Jaggar - Chloride signaling in endothelial cells
• 11:15 Madeline Nieves-Cintron - E-cigarette exposure alters cAMP signaling in vascular smooth muscle
• 11:40 Scott Earley - Orai channels and neurovascular coupling
• 12:05 Short Talk 7
• 12:20 Lunch break
• 14:00 End of the conference