Resolution of Pulmonary Fibrosis
Hôtel Dupanloup
1 rue Dupanloup
45000 Orleans
France
Presentation
Chronic pulmonary inflammation due to airborne pollutants leading to fibrosis with progressive loss of lung function is a major therapeutic challenge. Multiple mechanisms are involved, including airway cell death activating myeloid, innate and adaptive lymphoid cells with the release of inflammatory and pro-fibrotic mediators, fibroblast activation and proliferation with excessive collagen production.
Resolution of fibrotic pulmonary diseases is the focus of the present conference. Novel approaches using patient samples and experimental models, as well as the role of altered microbiota and metabolites, will be debated.
The commonly used experimental bleomycin-induced fibrosis model for IPF may provide insights into fibrosis resolution, unlike clinical IPF. Contributions on the polarization of myeloid cells, inhibition of fibroblasts, removal of fibrotic tissue or regeneration of alveolar epithelial cells by inhibitors and cell therapy are attractive. Therapies targeting specific molecular pathways enhancing fibrosis resolution is a major challenge for investigation.
This international conference is organised in the framework of the BIOPHARMACEUTICALS ARD CVL Programme.
Convenors
Prof. Remo C. Russo, LE STUDIUM Visiting researcher / ARD CVL biopharmaceuticals
FROM Federal University of Minas Gerais - BR
IN RESIDENCE AT Immuno - Neuro Modulation (INEM) / CNRS, University of Orléans - FR
Dr Valérie Quesniaux , Dr Bernhard Ryffel et Dr Isabelle Couillin
Immuno - Neuro Modulation (INEM) / CNRS, University of Orléans - FR
Location
Hôtel Dupanloup : 1, rue Dupanloup - 45000 ORLEANS - FR
The conference venue is unique. Located right next to the Orléans’ cathedral, the episcopal palace of Orléans, built between 1635 and 1641, locally known as the Hôtel Dupanloup, is a classical French building which served until 1905 of residence to the bishops of Orléans. Since 2014, the renewed palace hosts the International University Center for Research and Le Studium Loire Valley Institute for Advanced Studies.
Participants will be welcomed in this exceptional surrounding, blending Middle Age and Renaissance cultures with modern design and will have the opportunity to discover French cuisine and wines.
Programme
DAY 1 - Monday June 10th, 2024 - Innate immunity response and pulmonary fibrosis
- 09:00 Welcome coffee & registration
- 09:30 Official Opening - Valérie Quesniaux & Sophie Gabillet
- Remo C. Russo - Meeting purpose and objective: resolution of inflammation and fibrosis resolution paradigm
SESSION 1: Clinical features & mechanisms of lung fibrosis
Chairmen: Tobias Stoeger & Olivier Burgy
- 10:00 Arnaud Mailleux - Aberrant Cell Differentiation in Idiopathic Pulmonary Fibrosis: Emergence of Pathological Cell Types and Metaplasia of mesenchymal origin.
- 10:40 Coffee break
- 11:10 Herbert Schiller - Towards Precision Regenerative Medicine in Lung Fibrosis
- 12:00 Lunch
SESSION 2: Modeling pulmonary fibrosis and response to pollutants
Chairmen: Adriano Rossi & Bernhard Ryffel
- 13:30 François Huaux - Interpreting immunoregulation in lung fibrosis: a new branch of the immune model.
- 14:10 Tobias Stöger - Macrophage dynamics during nanoparticle triggered lung inflammation provoke pro-fibrotic cell circuits in mice
- 14:50 Marieke Lehmann - Spatiotemporal analysis of inflammaging and senescence programs in non-resolving lung fibrosis
- 15:30 Diana Porras-Gonzalez - Advancing models of human lung fibrogenesis for the discovery of anti-fibrotic strategies
- 16:00 Noria Segueni - Pollution and lung fibrosis : modeling asthma-COPD overlap in mice
- 16:30 Coffee break
SESSION 3: Role of Innate immunity in pulmonary fibrosis development
Chair(wo)men: Sylvain Perruche & Emeline van Goethem
- 17:00 Olivier Burgy - Intercellular communication and extracellular vesicles: the basis for new therapeutic options for pulmonary fibrosis
- 17:40 Isabelle Couillin - Sensing of danger signals leading to pulmonary inflammation and fibrosis
- 18:20 Guided visit of the city center
- 19:45 Wine & Cheese cocktail
Day 2 - Tuesday June 11th, 2024 - Resolution of inflammation in pulmonary fibrosis development
- 09:00 Welcome coffee
SESSION 4: Cellular mechanisms in resolution of inflammation and pulmonary fibrosis
Chairmen: Amiram Ariel & Remo Russo
- 09:20 Keynote: Sylvain Perruche - Reengagement of resolution to reverse fibrosis
- 10:10 Tatiana Victoni - Mechanisms for regulating chronic inflammation and the role of macrophages
- 10:50 Coffee break & Posters session
- 11:20 Stefano Rivetti - Fibroblast plasticity in lung fibrosis: myofibroblast and lipofibroblast switch
- 12:00 Anu Fernando - Modulating the Inflammasome pathways and macrophage activity through dual NLRP1 and NLRP3 inhibition to reduce inflammation and fibrosis in silicosis
- 12:20 Lunch
SESSION 5: Resolutive mediators & targeting resolution in pulmonary fibrosis
Chairmen: Stefano Rivetti & Mareike Lehmann
- 14:00 Amiram Ariel - New effectors in the Resolution of Inflammation and tissue fibrosis.
- 14:40 Emeline van Goethem - Pro-resolving mediators and transcriptomic signature of fibrosis
- 15:20 Remo Russo - Defective Resolutive program in Idiopathic Pulmonary Fibrosis?
- 16:00 Keynote: Adriano Rossi - Resolution of inflammation and fibrosis
- 16:50 Closing section
General Information
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Congress Venue |
Hôtel Dupanloup, 1 rue Dupanloup
45000 Orléans, France
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Dates |
Monday, 10 June - Tuesday, 11 June 2024
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Language |
The official language of the Congress is English
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Welcome pack and Name Badge |
Upon arrival you will receive a welcome pack that includes the printed material of the Conference and your name badge will be given to you at the reception . Please wear your name badge at all times during the Conference and to all official Conference events.
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Invitation Letters |
An official letter of invitation facilitating the obtention of an entry visa can be sent upon request . In order to receive an invitation letter for visa purposes, send an email to maurine.villiers@lestudium-ias.fr. Please note that :
- we only issue an official letter once the payment of the registration fee has been validated.
- such letters do not represent a commitment on the part of the Organisers to provide any financial assistance.
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Certificate of attendance |
After the conference, in order to receive a certficate of participation, send an email to maurine.villiers@lestudium-ias.fr
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Hotels |
List of recommended Hotels in Orléans
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Restaurant |
How to get there ?
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By train: |
* Orléans centre station
1.5 hour trip from Paris (Austerlitz)
* Les Aubrais station (4km from Orleans town centre)
Tramway A, 10 minutes trip to Orléans centre station
> Plan your trip by train: https://www.sncf-connect.com/en-en/
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By car: |
GPS: 47.90243, 1.91179
Please note that you can't park in the courtyard in front of the Hotel Dupanloup.
Paid car parks nearby :
Parking Cathédrale, Rue Saint-Pierre Lentin, 45000 Orléans
Parking Hôtel de Ville, 4 Rue Fernand Rabier, 45000 Orléans
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By plane: |
*Arrival at Roissy Charles De Gaulle (CDG) airport:
Take RER B in direction to Saint Rémy Les Chevreuse, step out at Gare du Nord Stop
Take Metro 5 in direction to Place d'Italie, step out at Gare d'Austerlitz Stop
> Then take a train to Orléans (see "by train" section above)
*Arrival at Paris-Orly (ORY) airport:
Take RER C from Pont de Rungis – Aéroport d’Orly in direction to Pontoise.
Step out at Gare d'Austerlitz Stop
> Then take a train to Orléans (see "by train" section above)
Pricing
(Including tow lunches, a wine & cheese cocktail and the coffee breaks)
| Public institutions | 280 EUR |
| Students & PhD Scholars | 100 EUR |
Cancellation Policy
All cancellations must be made in writing and sent by email to the Registration Department
Up to 30 days prior to conference start – Full refund less €50 handling fee
Less than 30 days prior to conference start – No refund
Oral presentations & posters
Abstracts for oral presentation and poster should be submitted before Monday 13th May 2024.
Please upload your abstract during the registration or send it before the deadline to maurine.villiers@lestudium-ias.fr.
The number of oral presentations is limited, convenors will process a selection and confirm your presentation few days later.
Please note that we do not print the posters, but racks & pins will be provided for up to A0 sizes, portrait format.
- Please download the template for oral presentation.
- Please download the template for poster presentation.
Partners of the event
