Presentation

Confirmed speakers

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• Prof. Mehdi Beniddir, Paris-Saclay University - FR

  

  Prof. Mehdi Beniddir

  BioCIS, Paris-Saclay University

  17, Avenue des Sciences, 91400 Orsay, France

  Email: mehdi.beniddir@universite-paris-saclay.fr
  Phone: (+) 33 1 80 00 63 43
   

  Mehdi Beniddir is a Professor of Natural Product Chemistry at the Faculty of Pharmacy of Paris-Saclay University. He obtained his PhD under the guidance of Dr Françoise Guéritte and Dr Marc Litaudon at the Institut de Chimie des Substances Naturelles (ICSN-CNRS) in 2012. After a post-doctoral period in the group of Prof. Erwan Poupon, he joined the Faculty of Pharmacy of Paris-Saclay University in 2014. His research interests include the streamlined discovery and structure elucidation of intricate natural substances from plants, marine invertebrates and micro-organisms using MS-based dereplication approaches. He is currently the coordinator of the IRN (International Research Network) “Integrative Natural Product Chemistry” (i-NPCHEM).

  Revisiting Previously Investigated Plants using Chemoinformatic Tools

  Landmark advances in bioinformatics tools and analytical chemistry, particularly in mass spectrometry (MS), have recently enhanced the field of natural product (NP) research, putting today’s practicing chemists in the enviable position of being able to efficiently speed up the NP discovery process. In this context, molecular networking, an emerging computer-based approach, has totally revolutionized the “art of NP isolation”, enabling the transition from the traditional “grind and find” model to the streamlined hypothesis driven targeting of NPs.
  As part of our continuing interest in monoterpene indole alkaloid (MIA) chemistry, we recently implemented an in-house MS/MS database, constituted of a cumulative collection of alkaloids from the global natural products research community. These endeavors led to the construction of the largest MS/MS dataset of MIAs to date, that we named: (MIADB). Thanks to this database, we developed a streamlined molecular networking dereplication pipeline directed toward the reinvestigation of previously studied MIA-containing plants. This pipeline allowed to prioritize the isolation workflow toward new alkaloids bearing unprecedented carbon skeleton and interesting biological activities. This presentation is intended to describe the most significant results gleaned from the reinvestigation of several forgotten plants by this new generation of sophisticated tools.
   

• Prof. Said Gharby , Ibn Zohr University Polydisciplinary Faculty of Taroudant - MA

  

  Prof. Said Gharby

  Ibn Zohr University Polydisciplinary Faculty of Taroudant
  Address: BP. 271, Taroudant 83000

  Email: s.gharby@yahoo.fr/s.gharby@uiz.ac.ma
  Phone: (+) 212694768189
   

  Said gharby was born in 1978 in Casablanca City, Morocco. He received his Ph.D. in analytical chemistry, from Faculty of Science, University Mohammed V Rabat, in 2012. He had published more than 90 papers in international journals and presented about seventy 70 communications in symposia and national/international meetings. 
  Since 2017, Said Gharby was appointed as a professor of analytical chemistry and quality control at the Polydisciplinary Faculty of Taroudant, Ibn Zohr University.
  Before joining the university as a professor, said Gharby has worked in the food industry at LESIEUR CRISTAL (2004–2011) in Casablanca, Morocco and then at Ministry of Agriculture, Autonomous Establishment of Control and Coordination of Exports, currently known as Morocco Foodex (2011–2017), Agadir, Morocco.

  Valorization of Argan oil:  Scientific Research to Enhance the Value of Argan Oil

  Argan oil (AO) has long been traditionally prepared by the Amazigh people in southern Morocco. However, the last twenty years were marked by a shift from traditional AO production to a semi-automated production within cooperatives. Whereas, artisanal oil was only intended to satisfy local, daily, and family consumption. The AO production by cooperatives using mechanical presses has made it possible to supply high quantity of AO at a large scale and of certified quality in terms of health and analysis. This has significantly improved the quality of the oil, enabling it to be marketed well beyond Morocco's borders and establishing its worldwide reputation. AO marketing is increasing steadily and considerably throughout the world. To maintain and expand its market share, Morocco needs to guarantee optimum conditions for the production of high-quality oils that meet the requirements of international standards.
  To accompany and support this strategy, our lab has initiated fundamental and applied research for the development and certification of Moroccan AO. Regarding applied research, we have focused particularly on AO quality. Our efforts have focused on studying the factors impacting on the quality of this oil, improving its preparation processes, its conservation, identifying fraud detection techniques and the influence of physical refining on AO quality including AO organoleptic properties. These studies have enabled us to identify several essential factors for the production of certified quality oil, and have led us to propose methods that can be easily used by the entire AO industry.

  Keywords: Argan oil; quality; stability and adulteration
   

• Dr Keshika Heas-Mahadeo, University of La Réunion - FR

  

  Dr Keshika Heas-Mahadeo

  University of La Réunion

  Address: CS 92003, 15 Av. René Cassin, Saint-Denis Cedex 9 97400, La Réunion

   Email: keshika.mahadeo@univ-reunion.fr

  Phone: (+262) 262 93 81 87

  Since 2022, I am associate professor in the laboratory CHEMBIOPRO (Laboratoire de Chimie et Biotechnologie des Produits naturels) at the University of Reunion Island. My research topics are focused on aromatic and medicinal plants. I mainly work on valorisation of plants and co-products through characterization of active compounds for cosmetics or pharmaceutics applications. 

  Valorisation of terpenes from Citrus peel waste 

  Terpenes are widely distributed compounds with a range of interesting industrial applications. Naturally occurring as major compound in several plants, cyclic monoterpenes are not valorised in the perfumery industry because of their high oxidation activity towards oxidants such as dioxygen.  Limonene, a cyclic monoterpene is an important bio-sourced component present in Citrus peels and can be produced on an industrial scale especially by the fruit juice industry in Reunion Island. Limonene represents more than 90% of tangor peel oil, which is not valorised yet in Reunion Island. Thus, it is an inexpensive precursor of flavour compounds. The project TERPENOX (FEDER funding) focused on the transformation of limonene and other monoterpenes into useful products. The transformation has been proceeded by catalytic oxidation using different metal catalysts through a modified Mukaiyama process. The reaction allowed the conversion of 95% of the limonene and a selectivity of 61% for limonene-1,2-oxide, the precursor of the flavour and fragrance agent trans-carveol. 
   

• Prof. Alessandra Lopes de Oliveira, University of São Paulo - BR

  

  Prof. Alessandra Lopes de Oliveira

  University of São Paulo (USP) - BR
  Address: FZEA/USP, Av. Duque de Caxias Norte, 225, Jdim. Elite, Pirassununga, SP, Brasil, CEP: 13635-005
  Email: alelopes@usp.br
  Phone: (+)55 19 992113200
   

  She is a Food Engineer with doctorate in Food Engineering. She was a visiting researcher at University of Orleans (ICOA). She is currently a full professor at the Faculty of Animal Science and Food Engineering at the University of São Paulo, Head of the Department and Coordinator of the Postgraduate Program in Food Engineering (PPGEA). She is a supervisor at PPGEA and a member of the International Master Program at University of Bordeaux (UFR of Pharmaceutical Sciences). She is a reviewer for several scientific journals with a safe editorial policy. Develops research in food engineering processes, with systems that use supercritical carbon dioxide and pressurized liquid extraction, working mainly on topics relating to optimization of green processes to obtain natural extracts.

  Processes that employ green technology to obtain extracts for use in functional foods and cosmetics

  The sustainable development goals (SDGs) agreed by 193 United Nations member states establish a new concept of development. The objectives to be achieved by 2030 aim to eradicate poverty, protect the environment and ensure that people live well. The 17 SDGs are interconnected and, in addition to eradicating poverty (SDG 1) and eradicating hunger (SDG 2), these actions aim to ensure well-being for all, at all ages (SDG 3), building resilient infrastructure, industrialization inclusive and sustainable development by promoting technological innovation (SDG 9), protecting and promoting the sustainable use of ecosystems, combating soil degradation, protecting forests and halting the loss of biodiversity (SDG 15).
  When we talk about producing natural extracts using clean and green technology, we are addressing SDGs 3, 9 and 15, as we employ technological innovation in the sustainable production of natural extracts. When active principles from forest plants are discovered, we begin to protect them, encouraging their maintenance. Furthermore, new extracts without residues of organic solvents are being generated with the purpose of use in food, pharmaceutical and cosmetic products. In this context, I will present the concepts and operational of two extraction processes that use health-safe and renewable solvents applied to obtain natural extracts (Supercritical Fluid Extraction and Pressurized Liquid Extraction). And finally, Microbiorefinery as a new concept of industrial production.
   

• Prof. Badiaa Lyoussi , University Sidi Mohamed Ben Abdallah - MA

  

  Prof. Badiaa Lyoussi

  University Sidi Mohamed Ben Abdallah - MA

  Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ),, University Sidi Mohamed Ben Abdallah, POBox 1796 Fez Atlas, Fez, Morocco

  Email: lyoussi@gmail.com
  Phone: (+) 212661354246
   

  Prof. Badiaa Lyoussi, Head of Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ), Member of the Apitherapy Commission of Apimondia, has a good experience over 30 years in the physiopathology and pharmacology of natural products. She had more than 206 scientific publications with h-index (41). She won the first price in the excellence for scientific research and innovation including active participation in innovative projects related to api-phytotherapy approach’s. She received a Doctorate from France since 1984 and a second PhD from Belgium since 1992.  She gives more than 60 conferences on bee products and medicinal plants in several countries and organized more than 30 international conferences on natural products and pathologies.

  Unveiling the techno-functional and bioactive properties of bee products in cosmetics

  Bee products have been used for skin care as ingredients of cosmetics. They possesses specific active substances which determine their use for various skin problems. 
  Honey is regenerative and antimicrobial. Propolis is rich in phenolic compounds, which determine antimicrobial, antioxidative and regenerative activities.  Bee pollen may effectively enhance protective mechanisms against skin aging, ultraviolet B radiation, oxidative damage, and melanogenesis. Royal jelly contains 10-hydroxy-trans-2-decenoic acid which improves the production of collagen and is antiseptic. Royal jelly is recommended to formulate cosmetic products with moisturizing, smoothing and general conditioning effects on the skin. Beeswax is one of nature’s best ingredients to use, and works as a thickening agent, emulsifier, and humectant. Beeswax is used for production of cosmetics and ointments in pharmacy. Bee venom (apitoxin) exhibit photoprotective and antiaging effect on the skin and stimulates the production of the naturally-occurring chemicals collagen and elastin. 
  This presentation will show some of our experience and others introducing bee products for health and cosmetic applications. Due to a large number of biological activities, bee products could be considered as important ingredients in cosmetics applied to skin.

  Keywords: Apicosmetics, bee products; flavonoids, phenolic acids, skin care, health ,  anti-oxidant, cosmetics, Protection.
   

• Dr Mahenina Jaovita Manase, University of Antsiranana - MG

  

  Dr Mahenina Jaovita Manase

  University of Antsiranana

  Address: BP0, Antsiranana 201

  Email: mmahenina@yahoo.fr
  Phone: (+) 261324059096
   

  Mahenina Jaovita Manase received his PhD in Pharmacognosy from the University of Burgundy, France. He is currently an associate professor at University of Antsiranana, Madagascar. His research interests are largely focused on the analytical chemistry of natural products from plants, as well as the use of various biological assays to assess the potential of these molecules. He is working on the development of an international project that aims to increase the value of plants that are traditionally used by the Malagasy people.

  From traditional use to successful well-being products: Illustrations through Malagasy Plants

  The exceptional biodiversity of Madagascar is distinguished by a high rate of endemic species, which play a vital role in the lives of the Malagasy people. Indeed, the island's flora serves as a source of traditional remedies and well-being deeply rooted in local culture, as evidenced by the Masojoany, combining a sun mask and a marker of cultural identity. The words of Professor Ratsimamanga, "Sublime is the science that aims to preserve life," perfectly emphasize how science, inspired by these traditional practices, has led to the development of exceptional products, such as the active ingredient derived from Centella asiatica, a cornerstone of the Centella Trademark’s organic cosmetic range, and the use of Harungana madagascariensis in Clarins cream lines. It is also fascinating to note that introduced plants, such as cocoa and Ylang-ylang, significantly contribute to the cosmetics industry with their valuable ingredients.

• Yolande Sandrine Mengue Ngadena , University of Yaoundé - CM

  

  Yolande Sandrine Mengue Ngadena

  University of Yaoundé 1

  Address: Department of Psychology, Faculty of Arts, Letters and Social Sciences, University of Yaoundé 1, 7073 Yaoundé-Cameroon

  Email: yolande.mengue@univ-yaounde1.cm

  Phone: (+) 237 699001781

  Sandrine Mengue is currently a Senior lecturer of Psychophysiology at the University of Yaoundé 1 (Cameroon). She earned her Master of Animal Physiology at the same university, in 2011, and her Ph.D. in the same field with an emphasis on nervous impairment linked to postmenopause in 2016.  Working with Prof. Paul Dzeufiet at the Laboratory of Physiology (168), in her thesis work, she pioneered the Suok test behavioral paradigm in ovariectomized rats for determining estrogen-like effects on brain disorders and evaluated estrogenic properties of Gouania longipetala on postmenopausal-related disorders.

  After completing her Ph.D., Sandrine accepted a position in 2018 as an Assistant research officer, at the Department of Animal Production and Fisheries, Institute of Agricultural Research for Development, Yaoundé, where she worked for 2 years.  During that time, she developed and used new instrumentation for performing high-yield fisheries and livestock by using plant or meal supplementation to reduce mortality. She is still working nowadays with her pass-collaborators.  Last year, she focused in particular on the effects of plant meal supplementation on egg quality, semen characteristics, and some Stress Markers in Brahma Chicken (Gallus gallus domesticus). This year they, evaluated the effect of feeds on the histopathology of gills, skin, liver, and kidneys of Clarias gariepinus (Burchell, 1822) reared in plastic tanks.

  In 2020, Sandrine accepted an Assistant position at the University of Yaoundé 1, where she has been since that time.  While at Yaoundé 1, Sandrine is actually the coordinator of the Neurosciences axis at the Laboratory of Development and Maldevelopment at the Department of Psychology. She has continued her work in pharmacology, metabolic diseases, and neurosciences. With constantly improving analysis of behavioral paradigm evaluation with any Maze software, she continued to evaluate antioxidant, anti-inflammatory, estrogenic, neuroprotective, antimicrobial, and antifungal properties of plant extract in different models. This program has evolved its focus in recent years to menopause consequences due to pleiotropic activities of estrogens that induce vasomotor symptoms, microbiota imbalance, neuronal disorders, psychological disorders, skin dryness and itches, osteoporosis, and vaginal dryness among others. Besides, she recently established in a rat model that postmenopausal status exacerbates stress-related neurological disorders in rats.

  Sandrine Mengue is affiliated with scientific societies like ALBA-Network, World Women in Neurosciences (WWN), and International Brain Organization (IBRO) and she is the vice regional representative of the Organization of Women in Science for Developing World Cameroon National Chapter, Centre Branch. Sandrine has 25 refereed publications in pharmacology, metabolic disease, and neurosciences.

  Phytochemical Profiling, in Vitro Biological Activities and in Silico Molecular Docking Investigations of a Traditional Palliative of Menopausal Symptoms: Pterocarpus soyauxii Taub. (Papilionaceae)

  Introduction: Menopause has clear consequences on the skin, such as a decrease in collagen and elasticity as well as an impact on common dermatoses. Herbal extracts are frequently included in cosmetic products because of a variety of related traits, such as their antioxidant properties. Pterocarpus soyauxii aqueous extract (PSAE) will be thoroughly investigated in this study to determine its phytocompounds, antioxidant, monoamine oxidase A (MOA A) inhibitor, anti-inflammatory, antibacterial, and antifungal potentials. Methods: Thus, colorimetric tests were used to assess the amounts of polyphenols, flavonoids, oxalates, phytates, saponins, and carotenoids in PSAE. Using its inhibitory effects on NADPH-Oxidase (NADPH-O) and lipid peroxidation, PSAE was subjected to an in vitro antioxidant study. Molecular docking calculations were used to identify the probable binding modalities of 7-O-acetyl formononetin, an isoflavone identified in PSAE to the MOA A and potential inhibitory mechanisms. Baicalin was compared to PSAE's in vitro alkaline phosphatase (ALP) activity, NO, 5-lipoxygenase (5-lox) inhibitions, and albumin denaturation. By calculating the Minimum Bactericidal/Fungicidal Concentrations (MBCs/MFCs) and Minimum Inhibitory Concentrations (MICs) against the bacteria E. coli and S. aureus and the fungus C. albicans, antimicrobial and antifungal properties of PSAE were evaluated. Results and discussion: The following compounds were shown to have significant concentrations per 100g of dry weight (DW) of polyphenols, flavonoids, tannins, saponins, phytates, oxalates, and carotenoids: 656.58±9.18 mg gallic acid equivalents, 201.25±5.52 mg quercetin equivalents, 18.42±1.25 mg, 6.37±0.14 mg, 5.24±0.92 mg, 7.35±0.52 mg, and 16.01±0.75 mg, respectively. Lipid peroxidation (IC50=684.27±8.47 µg/mL) and NADPH-O (IC50=524.25±12.54 µg/mL) inhibitions compared to ascorbic acid provided strong evidence of the PSAE's antioxidant activity. The 7-O-acetyl formononetin found in PSAE possesses the ability to cross the BBB and has a docking score of -9.69 kcal/mol. All residues on the MOA A's active site can react with this isoflavone.  Furthermore, PSAE displayed significant and concentration-dependent suppression of albumin denaturation, 5-lox, and enhanced ALP activity of macrophages when compared to baicalin at different doses (0.1-1000 g/mL). The IC50 ranges of PSAE are slightly larger (25.74-85.71 g/mL) than the standard (12.26 -25.74 g/mL), suggesting moderate enzyme inhibition that may prevent negative side effects. Although the MICs for S. aureus and E. coli are respectively 0.00097 and 0.0019 mg/mL, the MBC values for the two species are the same at 0.0039 mg/mL. For C. albicans, the MFC and MCI are 0.0019 and 0.00097 mg/mL, respectively. Conclusion: This study suggests that the PSAE had constituents (i.e., polyphenols, flavonoids, oxalates, carotenoids) with biological activities that can justify its incorporation in cosmetics for menopausal-related skin disorders. It lends credence to the folklore claims of P. soyauxii heartwood and reveals its potential as a possible source of bioactive compounds for medicinal and pharmaceutical exploration.

• Prof. Anne-Claire Mitaine-Offer, Centre for Taste and Feeding Behavior (CSGA) - FR

  

  Prof. Anne-Claire Mitaine-Offer

  Centre for Taste and Feeding Behavior (CSGA), UFR des Sciences de Santé, University of Burgundy

  Address: 7 Bd Jeanne d’Arc, 21000 Dijon

  Email: anne-claire.offer@u-bourgogne.fr

  Phone: (+) 33 3 80 39 34 74

  After a Pharmacy degree in 1993 at the University of Montpellier, I graduated a Ph.D. in Pharmacognosy in 1998, at the University of Reims Champagne-Ardenne (French Ministry of Higher Education and Research grant). Then, I have been recruited at the University of Bourgogne as associate professor in Pharmacognosy in 1999, and full professor in 2009. I have been at the head of the Laboratory of Pharmacognosy since 2018. The main topics of my research are phytochemistry, chemistry of natural compounds, glycosides, chromatography, structural analysis, 2D-NMR, structure/activity relationships. I am a member of the Center for Taste and Feeding Behavior (CSGA), CNRS, INRAE, Agro Institute, University of Burgundy, Dijon, France.

  Essential oils : Chemical composition and therapeutic uses

  The essential oils are highly valued by the public and are used in family medication, as cosmetics or hygiene products. However, they contain molecules known for their therapeutic or toxic activity depending on the dose. In this talk, the importance of the quality of these oils, depending on the raw material, their chemical composition, mostly mono- and sesquiterpenes, the notion of chemotaxonomy, and their extraction, will be discussed. When all these aspects of aromatherapy are taken into account, then, the therapeutic or cosmetic uses of these natural products can be done safely. Some examples of pharmaceutical and hospital aromatic protocols will be presented, using essential oils and the corresponding hydrolates too.

• Dr Marc Olivier, Sama Bioconsult Developpement - BF

  

  Dr Marc Olivier

  Sama Bioconsult Developpement - BF

  BP 1323 Bobo Dioulasso
  BURKINA FASO

  Email: oliviersama@yahoo.fr
  Phone: (+) (226) 76 60 97 80 / + (33) 6 08 56 37 94
   

  I am an ethnobotanist, studying and promoting of plants and traditions in Africa, particularly in Burkina Faso. I record and promote oral knowledges like traditional medicine.
  I am working with cosmetics companies to establish sustainable vegetal suply chains. This includes searching for plants with cosmetic potential, as well as addressing legislative and logistical aspects to facilitate local development actions. 
  I attach great importance to respect for people and nature. I was one of the founders of the International Forum Africa and Beauty, in 2004 with Mr Patrice ANDRE. I also carry local development actions thanks to funding from my partners in cosmetics, which support training initiatives, the construction of buildings, equipment, scholarships, etc.

  Interest of the ethnobotanical method in establishing sustainable plants supply chains for cosmetics in Burkina Faso

  We will present Burkina Faso, a Sahelian country with strong potential for ethnobotanical studies and the development of traditional cosmetic supply chains, through ethnobotanical methods.

  We present several species who leads to cosmetic active ingredients, explaining their traditional uses, phytochemical studies and efficacy tests and present sustainable supply chains:
  -    Baobab Oil and Fruit powder, Greentech SA
  -    Papaya leaves, Esprit d’Ethique
  -    Acacia seeds, Laboratoires Expanscience
  -    Mango Tree leaves, Givaudan
  -    Anogeissus bark, Givaudan
  We integrate good harvesting, drying, packaging practices, training in the management f local associations. Our approach emphasizes importance of quality and safety, while respecting both the local populations and environment. We take into account both local and international legislations, implementation of certain certifications (Organic, UEBT, active or in progress).

  Finally, we will discuss local development actions financed by cosmetic partners from France for Burkina Faso, which constitute a significant aspect of my work, taking into account needs of local partners and many actions concerning the study and protection of Nature.

  As a conclusion, we will highlight the demonstrated interest of ethnobotany and the potential of Sahelian plants for cosmetics, including the establishment of balanced and sustainable partnerships with external companies, respectful of socio-economic and environmental aspects.
   

• Celina Rocquet , Union for Ethical BioTrade (UEBT) - NL

  

  Celina Rocquet

  Union for Ethical BioTrade (UEBT) - NL
  Address: De Ruijterkade 6, 1013 AA,

  Amsterdam, the Netherlands

  Email: celina@uebt.org
  Phone: (+) 33 6 89 95 26 83
   

  Celina is an expert on access and benefit sharing (ABS) and provides technical expertise on issues related to innovation and sourcing of biodiversity. For the past 22 years, she worked in the cosmetic industry, both for ingredient suppliers and brands. She specialized in sustainable innovation and has been a consultant for life science based industries since 2010, especially on ABS. She also worked with the GIZ. Since 2007, she has trained companies and students on sustainable development, innovation and geopolitics & SDG. Celina holds a Master in Molecular and Plant Biology, as well as in Marketing.

  ABS and research: what to expect?

  Over the past decade, the concept of ABS (Access and Benefit-Sharing) has emerged as a crucial regulatory mandate that has commanded the attention and resources of numerous organizations. ABS is a multifaceted domain that engages various departments within these organizations, with a significant emphasis on research. In this presentation, we aim to explore the underlying factors contributing to this extensive involvement and delve into the intricate interconnections between ABS and research, spanning both academic and applied realms.

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