Knee Osteoarthritis Predictive Imaging Consortium

1st meeting

MEMBERS

• Dr Eric Lespessailles
  Imagerie Multimodale Multiéchelle et Modélisation du Tissu Osseux et articulaire (I3MTO) / University of Orléans - FR
• Dr John Lynch
  University of California San Francisco School of Medicine - US
• Dr Simo Saarakkala
  University of Oulu Faculty of Medicine - FI
• Dr Pawel Podsiadlo
  Curtin University Faculty of Science and Engineering - AU
• Dr Richard Ljuhar
  Danube University Krems - AT

Collaborator

• Dr Thomas Janvier, University of Orléans - FR

Description

Osteoarthritis (OA) is the most common disorder of the musculoskeletal system and the major cause of reduced mobility among seniors. It is now considered as a disease of the whole joint organ involving the articular cartilage, subchondral bone and synovial membrane but also the menisci and ligaments. However, the underlying mechanisms through which this debilitating disease occurs and progresses have not been fully elucidated yet. Moreover, there is still no medical treatment for this pathology, and the lack of predictive biomarkers is a major obstacle to their development.

The past years have shown many studies based on the computer-aided diagnosis for knee osteoarthritis, and more recently the prediction of the disease progression. Several research teams around the world have proposed their own methods for imaging markers extraction, but yet no clinical tools have emerged for knee osteoarthritis routine evaluation. Also, the development of high-end imaging modalities (high resolution MRI, quantitative µCT, ...) highlighted deep features (anisotropic bone microarchitecture, uncorrelated multiscale changes, ...) that were not systematically transposed to the highly available modalities.

This STUDIUM consortium aims to gathers experts from several imaging areas focused on the knee osteoarthritis in order to provide a synthesis of the good practices to assess OA related imaging biomarkers. A secondary objective is to include clinicians to help explain the underlying mechanisms observed or revealed by machine learning.

The ultimate goal is to melt the data driven predictive models into an actual diagnostic aid tool for clinicians.

Programme

Tuesday June 11th 2019

• 09:00    Arrival of attendees / coffee
• 09:30    Presentation of the host team
  • The I3MTO lab
    • The team
    • Fields of investigation
    • Consortium aims and operation)
• 10:30    Presentation of the attendees / consortium discussion
  • Each partner is invited to present his background, team and laboratory
  • Discussion about the consortium logistic and expectations
• 13:00    Lunch at the restaurant – L’agora (8) – Campus de l’Université d’Orléans​

​Afternoon is dedicated to the visit of the University campus, regional hospital of Orleans and translational research platform.

Wednesday June 12th 2019

• 09:00    Short literature review
  • The host team will present a short review of the papers selected for the Consortium preparation.
  • All partners are invited to prepare a selection of papers and studies related to the knee osteoarthritis imaging (disease classification and prediction) with a focus on conventional radiography.
  • A synthetic state of the art will be discussed as a baseline for the group work.
• 11:00    Consortium framing
  • Definition and framing of concrete objectives for the Consortium.
    • Review papers / potential white paper on guidelines for osteoarthritis imaging in texture analysis, segmentation, machine / deep learning on conventional radiographs.
    • Software prototypes
    • Clinical tools…
    • Each team presents its relevant detailed methods and lists its tools and means possibilities.

• 12:30    Lunch at the restaurant – Le Tonnelier (8) - 5 Rue d'Alsace Lorraine (Orléans)
• 14:00    Tasks distribution
  • Tasks distribution between partners, putting in place of tools/methods of collaboration and follow up.
  • First draw of a planning including the milestones

• 18:00    Guided visit of the city centre – Departure in front of the Hôtel Dupanloup
• 19:30    Dinner at the restaurant - Ver Di Vin (7) – 2 rue des Trois Maries (Orléans)

Thursday June 13th 2019

• 09:00    Practical implementation of a blind comparative study
  • Define a mini-project with the first tasks of the consortium roadmap, as a challenge between teams in order to test the frame and objectives between visits one and two of the studium consortium.
• 12:30    Lunch at the restaurant - Le Brin de zinc (6) - Rue Sainte-Catherine (Orléans)
• 14:00    Adjustment
  • Presentation of potential publicly available data base: OAI, MOST, FNIH OA biomarkers consortium…
  • Presentation of the European opportunities for science project (H2020, …)
  • Presentation of partners opportunities for strengthen the consortium (scientific societies relationships, workshops, open science projects…)

Friday June 14th 2019

• 09:00    Roadmap of the consortium
  • Identification and selection of the potentially relevant partners which should be included in the project.
  • Consortium planning validation.
  • Definition of the second and following visit (dates, partners to invite, milestones and deadlines…)

• 12:30    Lunch at the restaurant – L’ardoise (6) - 27 Rue de la Bretonnerie (Orléans)
• 14:00    Relationships and opening

Discussion about the possible links with OARSI-OMERACT and others learned societies.