Arc synaptic plasticity consortium

Coordinator of the consortium: Dr Lucie Pellissier, Physiology of Reproduction and Behaviour (PRC) / Centre INRAE Val de Loire, CNRS, University of Tours, IFCE - FR

Summary

Our abilities to learn, memorize new information and adapt to a new environment depend greatly on synaptic plasticity – the remarkable ability of our brains to adapt their synapses in response to different stimuli. A master regulator of this process in mammals is the neuronal immediate-early gene Arc, which is crucial for learning and memory consolidation. Interestingly, Arc can oligomerize into higher-order oligomers and consequently form viral-like capsids. Thus, this domesticated retroviral protein Gag could traffic and transfer mRNA material between neurons. Despite the known importance of Arc in synaptic plasticity, the exact regulation of this protein, its cellular functions, and its implication in different types of behavior remain a mystery. Therefore, our consortium gathering the complementary expertise of European researchers has the common goal to understand of Arc function and importance in the brain. To achieve this ambitious goal, we have developed antibody fragments to manipulate Arc in vitro and in vivo following three main research topics. First, we will focus on its dynamic regulation of Arc expression and cellular functions by using novel imaging methods and approaches. Additionally, we will try to elucidate the physiological role and significance of Arc oligomerization and viral-like capsids formation. Finally, we will address the role of Arc in behavior to inspect its precise role in the functioning of mammals. This consortium funded by Le Studium creates the unique opportunity to unravel the mystery of the Arc protein.

This consortium is organised in the framework of the ARD CVL BIOPHARMACEUTICALS Programme.