Infectious Diseases and Public Health (ISP)

According to the «One Health» concept, the JRU ISP conducts its research from three complementary and interconnected angles:

• Understanding the host response(s) to infections
• Understanding how the pathogens respond to their environments
• Developping innovative prevention and control strategies.

Research topics:

Infectiology according to the «One Health» concept:

• Microbial infections (bacteria, virus, parasite) and protective immunity versus exacerbated inflammation
• Virulence mechanisms of pathogens, escape to the host and resistance to drugs; impact of microbiota -mainly gut- on the development, maturation and evolution of the immune response; evolution and adaptation of the pathogens communities to their environment(s)
• Decipher the functions of different microbiota
• Host-directed therapies and Innovative biotherapies, New vaccines, adjuvants and platforms

Equipment and technology:

• Biosecurity laboratories of level 2 and 3 (BSL2 and BSL3)
• BioMark HD (medium-hight throughput ranscriptomic)
• Flow cytometry : analysis (BD LSR Fortessa X20) and sorting (MoFo Astrios, Beckman)
• IVIS Spectrum (in vivo imaging, bioluminescence and fluorescence)
• Leica SP8 spectral confocal microscope with high resolution scanning
• Hypoxia chamber for cell culture and infections (HypoxyLab, 2B innov)
• Chromium Controller (10x Genomics) for single cell analysis
• New generation sequencing (MinION, Oxford Nanopore Technologies)