Yun Hee Jang,Yves Lansaca
:
:
Download PDF

A theoretical prediction of favorable ion exchange between PEDOT:PSS and hard-cation-soft-anion ionic liquids (IL) is confirmed experimentally and computationally by treating PEDOT:PSS with a new IL composed of an extremely hard protic cation MIM+ and an extremely soft anion TCB–. This protic IL significantly improves both conductivity and stretchability of PEDOT:PSS, outperforming its aprotic counterpart, EMIM :TCB, which has been the best IL employed for this purpose so far. This electrical and mechanical enhancement is speculated as a result of the aromatic and protic cation MIM+ which does not only provide efficient ion exchange with PEDOT:PSS but also serves as a molecular glue holding together multiple PEDOT domains by strong ionic as well as hydrogen bonds, because washing MIM+ out of the film degrades the stretchability while keeping the morphology. Our results offer molecular-level insights on the morphological, electrical, and mechanical properties of PEDOT:PSS and a molecular-interaction-based enhancement strategy for intrinsically stretchable conductive polymers.

Patrícia S. Golo1,2, Julien Pichon3, Fotini Koutroumpa4
:
Download PDF

The Poultry Red Mite is considered the number one arthropod enemy of the poultry industry; despite this, this pest is hardly studied in terms of alternative control. The enormous economic loss they caused worldwide and the inefficacy of its control urge for solid solutions. One of the reasons why Dermanyssus gallinae is so challenging to manage is its hiding nature. Indeed, no treatment can reach them efficiently in their hiding spots. The idea of this project is to study the chemical ecology of the mite to attract it out of its hideouts. Le Studium Foundation has been instrumental in bringing together Prof Patricia Golo, an entomopathogenic-fungi specialist, and Dr. Fotini Koutroumpa, a specialist on arthropod chemosensation. Here, we would like to report preliminary results for optimizing the mite olfactory behavior tests in the laboratory and the first attempt to study one chemosensory gene expression of the mite. Comparison of these assays between fungus-treated and untreated mites was the goal of the project to understand if the entomopathogenic fungi could change the mite chemosensation and, therefore, negatively impact the fungus treatment. Further, we aimed to understand if a generally considered attractive molecule could enhance mite control with the fungus by masking the fungus's eventually repulsive molecules or/and attracting the mite to the fungus source. This collaboration set the base for further exchange to attend to these goals.

Alberto Campagnolo
:
Download PDF

This paper explores the significance of photogrammetry as an accessible and innovative imaging technique for preserving and studying written cultural heritage. Focusing on the challenges of traditional digitization methods in capturing the materiality and craftsmanship of manuscripts and books, we present a cost-effective photogrammetry workflow using the 3DF Zephyr software. Demonstrating its potential, we discuss the generation of detailed 3D models and the integration with other software tools. The research findings were presented at the 19th International Seminar on the Care and Conservation of Manuscripts, and the paper is planned for publication in the conference proceedings. This work contributes to the broader discourse on Digital Codicology and encourages interdisciplinary collaboration in cultural heritage studies.

Michal Korenko1,2 and Mathieu Allix2
:
:
Download PDF

The primary aim of this Le Studium project was a thorough physico-chemical analysis and structural characterization of key phases and compounds of high-temperature fluoride melt/solid interphases. This knowledge is then used for a targeted synthesis and preparation of different compounds and materials (including their physicochemical characterization), based on oxo-fluoro-aluminates of alkali metals. 

 

 

Camille Caussette, Ely Cheikh Mohamed Ewe, Maxime Guéguinou, Karine Mahéo, Christophe Vandier, Thierry Brouard and David Crottès
:
:
Download PDF
Cancers are highly heterogeneous. This intra-tumoral heterogeneity contributes to the tumor development by confering new features such as drug resistance or aggressiveness. Understanding how this heterogeneity arises and how to detect it is a promising challenge to improve diagnosis and therapies. Aberrant regulation of calcium homeostasis in cancer cells has been extensively described. However, the relationship between calcium homeostasis and tumor heterogeneity remains to be explored.
In this project, we hypothesized that the profile of calcium homeostasis could be indicate of the phenotype of the cancer cell. We aim to develop a workflow allowing to classify cancer cells according their profile of calcium responses. We generated a database of single cell calcium responses elicited by various molecules in a panel of colorectal and prostate cancer cell lines. Using unsupervised classification algorithms, we successfully develop a model defined several profiles of calcium responses. Using this model, we were able to distinguish the origin of cancer cells.
These results suggest that calcium profiling could be an effective tool to discriminate different sub-populations of cancer cells. Further experiments will be required to develop and improve this model.

Benjamin Gory is a Full Professor of Interventional Neuroradiology at the University Hospital of Nancy (CHRU de Nancy) in France. He is an accomplished clinical researcher and a leading figure in the field of interventional neuroradiology. As a French trialist, he serves as the coordinating investigator for several ongoing randomized controlled trials, including the Direct Angio trial and the TITAN trial. His research focuses on acute stroke management, aiming to improve patient outcomes through innovative interventional strategies.

Prof. René Chapot is a world-renowned neurointerventionalist and a leading expert in the treatment of arteriovenous malformations (AVMs). He currently serves as the Head of the Department of Neuroradiology and Endovascular Therapy at the Alfried Krupp Krankenhaus in Essen, Germany.

Consultant Neuroradiologist

Good quality images will save your day: Complex cases

High-quality imaging can be your best ally in the angiosuite. In this presentation, I will review a series of real-life cases where optimal image acquisition proved critical in guiding the operator’s understanding, decision-making, and therapeutic strategy adjustments.

Fouzi Bala is an interventional neuroradiologist (MD, MSc) at Tours University Hospital. After his diagnostic and interventional neuroradiology training at Lille University Hospital, he did a research fellowship at the Kings College Hospital in London and then within the renowned Calgary Stroke Program. During his stay in Calgary, he led the imaging core lab of the randomized trial AcT and has been actively involved in the EVOLVE trial. His research interest focuses on thrombus imaging and the improvement of mechanical thrombectomy techniques.

Johannes Kaesmacher is a clinician-scientist (MD, PhD) and interventional neuroradiologist with a strong background in stroke treatment and clinical stroke research. After initial training in Munich, he is currently an Associate Professor at the Medical Faculty of the University of Bern and a Research Group Leader at the Stroke Research Center Bern. He also serves as an attending physician at the University Hospital Bern. His research focuses on adjuvant medical therapies and new imaging techniques during acute interventional stroke treatment.